If you are using Meggy Jr with the Serial-to-USB Cable provided in the Evil Mad Scientist shop you might encounter the following error:
avrdude: stk500_getsync(): not in sync: resp=0x00
avrdude: stk500_disable(): protocol error, expect=0x14, resp=0x51
The error manifest while uploading a new sketch to Meggy. If you pull out the USB cable and plug it in again you can upload a sketch successful. But on the next time you try you’ll get the error again. Luckily there is a pretty simple solution. I found it while digging through the Evil Mad Scientist Forums. It involves setting the “Set RTS on close” flag of the COM Port. You can do this in the Device Manager. Find the COM Port that was installed when you first plugged in the USB-to-Serial cable. For me it’s COM3. In the connection settings click on details and mark the flag selected. That’s it. I tried this on Windows XP with Service Pack 3, but it should work similiarily on other Windows versions.